Reliable, consistent and detailed spatial-temporal data, information and knowledge on infrastructure assets is essential to inform the long term delivery of infrastructure systems. To leverage maxim utility integrated data management, analysis, modelling and visualisation environments are required for this purpose. Within the UK Infrastructure Research Transitions Consortium (ITRC) a national scale spatial database, analysis and modelling system (NISMOD-DB) has been developed, that contains national scale data and information on infrastructure assets and networks, as well as, information and knowledge on the geotemporal patterns of infrastructure demand, supply and capacity. In this paper we describe the main components of NISMOD-DB and how it can be used within infrastructure systems research.