In this paper, regional freshwater demands for the electricity sector (cooling water for power stations) are investigated against regional freshwater availability at low flows in a scenario of medium climate change. In a future with high levels of fossil fuel generation with carbon capture and storage, electricity sector water demands are expected to greatly exceed current and future availability in the north-west (NW) England, Humber, East (E) Midlands and Thames regions. The research was part of the ITRC programme, involving researchers from Newcastle, Cardiff and Oxford Universities.